Table II.
Epitopes with >80% positive rate at all 3 sampling time points
| Protein | Subunit | Peptide ID | Peptide sequence | Positive response frequency |
||
|---|---|---|---|---|---|---|
| Days 10-60 | Days 100-150 | Days 180-220 | ||||
| IgG | ||||||
| ORF1ab | nsp3 | 1201 | 2313-SFKWDLTAFGLVAEW-2327 | 0.94 | 0.83 | 0.87 |
| nsp3 | 1208 | 2341-LGLAAIMQLFFSYFA-2355 | 0.89 | 0.94 | 0.93 | |
| nsp3 | 1280 | 2629-VLSTFISAARQGFVD-2643 | 0.94 | 1.00 | 1.00 | |
| nsp5 (3CL pro) | 1478 | 3421-SFCYMHHMELPTGVH-3435 | 0.89 | 0.89 | 0.93 | |
| nsp8 | 1630 | 4029-MQTMLFTMLRKLDND-4043 | 0.94 | 0.89 | 0.93 | |
| nsp13 (helicase) | 1985 | 5449-TCTERLKLFAAETLK-5463 | 0.89 | 0.89 | 0.87 | |
| nsp13 (helicase) | 2073 | 5801-KGVITHDVSSAINRP-5815 | 1.00 | 1.00 | 1.00 | |
| nsp14 | 2140 | 6069-DQFKHLIPLMYKGLP-6083 | 1.00 | 0.94 | 1.00 | |
| S | S1, NTD | 318 | 45-SSVLHSTQDLFLPFF-59 | 1.00 | 0.94 | 1.00 |
| S2, FP | 510 | 813-SKRSFIEDLLFNKVT-827 | 0.94 | 0.94 | 1.00 | |
| IgM | ||||||
| ORF1ab | nsp2 | 685 | 249-YELQTPFEIKLAKKF-263 | 0.89 | 0.94 | 0.93 |
| nsp2 | 822 | 797-EKYCALAPNMMVTNN-811 | 0.94 | 1.00 | 1.00 | |
| nsp3 | 1123 | 2001-ATYKPNTWCIRCLWS-2015 | 0.83 | 0.83 | 0.87 | |
| nsp3 | 1275 | 2609-LKTLVATAEAELAKN-2623 | 0.89 | 0.94 | 0.93 | |
| nsp3 | 1280 | 2629-VLSTFISAARQGFVD-2643 | 0.89 | 0.94 | 0.87 | |
| nsp4 | 1420 | 3189-MYLKLRSDVLLPLTQ-3203 | 0.83 | 1.00 | 1.00 | |
| nsp5 (3CL pro) | 1452 | 3317-YEDLLIRKSNHNFLV-3331 | 0.83 | 0.94 | 0.93 | |
| nsp5 (3CL pro) | S4 | 3353-KVDTANPKTPK-3363 | 0.83 | 0.89 | 1.00 | |
| nsp5 (3CL pro) | 1478 | 3421-SFCYMHHMELPTGVH-3435 | 0.94 | 0.94 | 0.93 | |
| nsp5 (3CL pro) | 1509 | 3545-LGSALLEDEFTPFDV-3559 | 0.89 | 0.94 | 1.00 | |
| nsp8 | 1616 | 3973-SEVVLKKLKKSLNVA-3987 | 0.89 | 0.89 | 1.00 | |
| nsp8 | 1623 | 4001-LEKMADQAMTQMYKQ-4015 | 0.83 | 0.83 | 0.93 | |
| nsp8 | 1630 | 4029-MQTMLFTMLRKLDND-4043 | 1.00 | 0.94 | 1.00 | |
| nsp8 | 1637 | 4057-VPLNIIPLTTAAKLM-4071 | 0.94 | 0.94 | 1.00 | |
| nsp9 | 1682 | 4237-LNRGMVLGSLAATVR-4251 | 0.83 | 1.00 | 1.00 | |
| nsp10 | 1690 | 4269-FCAFAVDAAKAYKDY-4283 | 0.94 | 1.00 | 1.00 | |
| nsp12 (RdRp) | 1746 | 4493-FFKFRIDGDMVPHIS-4507 | 0.83 | 0.83 | 0.87 | |
| nsp12 (RdRp) | 1845 | 4889-NLDKSAGFPFNKWGK-4903 | 0.89 | 0.83 | 0.87 | |
| nsp13 (helicase) | 1985 | 5449-TCTERLKLFAAETLK-5463 | 0.94 | 0.89 | 1.00 | |
| nsp13 (helicase) | 2006 | 5533-VVYRGTTTYKLNVGD-5547 | 0.83 | 0.89 | 0.87 | |
| nsp13 (helicase) | 2052 | 5717-AKHYVYIGDPAQLPA-5731 | 0.94 | 1.00 | 1.00 | |
| nsp13 (helicase) | 2065 | 5769-PAEIVDTVSALVYDN-5783 | 0.94 | 0.94 | 0.93 | |
| nsp13 (helicase) | 2070 | 5789-KDKSAQCFKMFYKGV-5803 | 0.94 | 0.83 | 0.87 | |
| nsp13 (helicase) | 2073 | 5801-KGVITHDVSSAINRP-5815 | 1.00 | 1.00 | 1.00 | |
| nsp14 | 2140 | 6069-DQFKHLIPLMYKGLP-6083 | 1.00 | 0.94 | 1.00 | |
| nsp14 | 2162 | 6157-GFDYVYNPFMIDVQQ-6171 | 0.89 | 0.94 | 0.87 | |
| nsp16 | 2350 | 6909-LIGDCATVHTANKWD-6923 | 0.83 | 0.89 | 0.87 | |
| nsp16 | 2370 | 6989-TAFVTNVNASSSEAF-7003 | 0.94 | 1.00 | 0.93 | |
| nsp16 | 2382 | 7037-LSSYSLFDMSKFPLK-7051 | 0.89 | 0.94 | 0.93 | |
| S | S1, NTD | 318 | 45-SSVLHSTQDLFLPFF-59 | 0.94 | 0.94 | 1.00 |
| S1, NTD | 356 | 197-IDGYFKIYSKHTPIN-211 | 0.89 | 0.89 | 1.00 | |
| S2, FP | 510 | 813-SKRSFIEDLLFNKVT-827 | 0.94 | 0.94 | 1.00 | |
| S2 | 530 | 893-ALQIPFAMQMAYRFN-907 | 0.83 | 0.83 | 0.93 | |