. 2022 Jan 4;15(1):66. doi: 10.3390/ph15010066

Table 1.

Various pharmacokinetic parameters of common oxime based antidotes. (t_1/2: half-life excretion time; C_max: maximum concentration in blood plasma; and T_max: time to reach C_max). (C_max and T_max listed for injected concentrations not exceeding 50 mg/kg).

Oxime	EC₅₀ (mg/L)	T_max (min)	C_max (µM)	T_1/2 min	Status
2-PAM [62]	4.67	10	37–132	37.6–55	Approved
Obidoxime [73,74,75]	57.0	4.5	78	28.4	Approved
HI-6 [37,73,76]	304	5.8	138	25.7	Approved
RS194B [77]	ND	5	112	52	Candidate
K027 [76,78]	229	5	586	60	Candidate
K203 [79]	ND	22	242	101	Candidate