Fig. 6.

Difference in T-cell propensity and T-cell epitope combined score between reference and mutated peptides. A. After proteasome cleavage simulation, we obtain 1513 peptides that are common between the reference and the mutated virus. A small number of peptides are only present either in the reference virus or in the mutated virus. B. The distribution of T-cell propensities estimated by NetTepi is not affected by the D614G mutation (p = 0.99 according to the Kolmogorov-Smirnov test) while a significant change is observed for the S939F mutation (p = 0.01 according to the Kolmogorov-Smirnov test). The boxplot reports median and quartiles of the data. C. The mutations affect the T-cell epitope combined score of the peptides estimated by NetTepi in a HLA-dependent manner.