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Extracted ion chromatograms for m/z 441 (AFB2a-Lys) when the coupling reaction proceeds at (a) pH 8 and (b) pH 10. The minor, earlier eluting peak is the undesired α-amino linked AFB2a-Lys while the major, less polar peak is the target ε-linked (c) AFB2a-lys. Although AFB2a-ε-Lys is the favoured product across the tested pH range, a higher pH favours its production and is associated to the degree of protonation.
