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Influence of MTX treatment on folate concentrations and RBC disposition of MTX in the CIA mouse model. Comparison of (A) RBC 5mTHF, (B) Plasma 5mTHF, (C) RBC CH=THF, and (D) polyglutamate distribution of RBC MTX in healthy control (con; blue; n = 10), CIA disease mice (dis; orange; n = 8), and CIA disease mice treated with MTX (dis + MTX; yellow; n = 9).
