Table 1.
Different formulations used for niosomes preparation with their physical properties including size, PDI, and EE%. In this chart, NL, NLC, and NLCPFA are unloaded, drug-loaded, and functionalized drug-loaded niosomes, respectively.
| Sample | Surfactant: Cholesterol (Molar Ratio) | Lipid: Drug (Molar Ratio) | Let (mg) |
Cyclo (mg) |
Size (nm) |
PDI | EE (%) | |
|---|---|---|---|---|---|---|---|---|
| Cyclo | Let | |||||||
| NLC | 1:1 | 10:1 | 10 | 10 | 224.7 ± 6.4 | 0.224 ± 0.009 | 89.60 ± 0.86 | 91.58 ± 0.96 |
| NLC | 2:1 | 10:1 | 10 | 10 | 231.3 ± 7.2 | 0.257 ± 0.011 | 92.75 ± 1.06 | 93.50 ± 1.12 |
| NLC | 1:1 | 20:1 | 10 | 10 | 251.7 ± 5.3 | 0.249 ± 0.010 | 91.39 ± 0.98 | 94.85 ± 1.23 |
| NLC | 2:1 | 20:1 | 10 | 10 | 240.9 ± 4.4 | 0.198 ± 0.008 | 93.95 ± 1.36 | 96.22 ± 1.42 |
| NLCPFA | 2:1 | 20:1 | 10 | 10 | 213.9 ± 3.2 | 0.143 ± 0.007 | 94.10 ± 1.85 | 98.50 ± 1.88 |
| NL | 2:1 | 20:1 | - | - | 186.1 ± 3.1 | 0.158 ± 0.009 | - | - |