. Author manuscript; available in PMC: 2022 Jan 21.

Published in final edited form as: Muscle Nerve. 2021 Jul 23;64(4):467–473. doi: 10.1002/mus.27371

Table 1.

Parameters for time-to-event analyses of loss-of-ambulation (LoA) from the parent CINRG-DNHS (n = 212).

Cox regression factor	Level of factor	N	%	LoA events (n, %)	Median age (years) at LoA (95% CI)	HR (95% CI)	p-value
DMD pathogenic variant alocation	Proximal to 5’ DMD intron 44	66	31%	34 (52%)	12.5 (11.2 – 18.1)	0.85 (0.57 – 1.27)	ns
DMD pathogenic variant alocation	Distal as those including nucleotides 3’ DMD including intron 44	146	69%	98 (67%)	12.0 (11.5 – 13.0)	1 ^*	-
Corticosteroid treatment	Untreated or treated for less than one year	55	26%	48 (87%)	9.7 (9.0 – 11.0)	1 ^*	-
Corticosteroid treatment	Treated at least for 1 year while ambulatory	157	74%	84 (54%)	13.5 (12.5 – 14.0)	0.24 (0.16 – 0.35)	*<0.0001*
Total		212	100%	132 (100%)	12.0 (11.5 – 13.0)	-	-

LoA: loss of ambulation; CI: confidence interval; HR: Hazard Ratio.

A HR of 1 is given for factor levels that are taken as reference in the Cox regression model.