. Author manuscript; available in PMC: 2022 Jan 21.

Published in final edited form as: Muscle Nerve. 2021 Jul 23;64(4):467–473. doi: 10.1002/mus.27371

Table 5.

Analysis of 3-year change in 6-minute walk test in subjects with proximal and distal DMD pathogenic variants.

Cohort	Age^*	N (obs.) N (indiv.)	Baseline 6MWT (Mean ± SE)^**	6MWT at 3 years (Mean ± SE)^**	Calculated 3 year change in 6MWT^***
All	< 7 years	189 49	353 ± 15	439 ± 31	85.7
All	≥ 7 years	188 71	393 ± 15	337 ± 17	−55.2
*Proximal DMD* pathogenic variants**	< 7 years	45 12	324 ± 38	341 ± 52	16.8
*Proximal DMD* pathogenic variants**	≥ 7 years	47 22	395 ± 29	331 ± 34	−64.4
*Distal DMD* pathogenic variants**	< 7 years	144 37	363 ± 16	454 ± 13	91.0
*Distal DMD* pathogenic variants**	≥ 7 years	141 49	391 ± 17	339 ± 19	−52.2

Note an individual can be in both the <7 and ≥ 7 years sub-cohorts at different times based on age. A participant can contribute assessments while younger than 7 in one model and contribute assessments while 7 or older to the other model.

^**

Mean and SE are predicted values from longitudinal model.

^***

Change over three years is based on the rate of change (coefficient) for the model.