Table 1.

Microwave-assisted amide synthesis ¹.

Entry	Nomenclature	X	Y	Yield (%) 2
1	8a	CH2	H	50
2	8b	N-Boc	H	70
3	8c	O	H	43
4	8d	S	H	82
5	8e	CH2	F	19
6	8f	N-Boc	F	62
7	8g	O	F	52
8	8h	S	F	42
9	8i	CH2	Cl	19
10	8j	N-Boc	Cl	69
11	8k	O	Cl	27
12	8l	S	Cl	51
13	8m	CH2	Br	27
14	8n	N-Boc	Br	56
15	8o	O	Br	66
16	8p	S	Br	83 (44) 3
17	8q	CH2	CH3	30
18	8r	N-Boc	CH3	57
19	8s	O	CH3	31
20	8t	S	CH3	57

¹ Reaction conditions: 3 (0.65 mmol), 7 (0.5 mmol), HATU (0.5 mmol), EDC (0.5 mmol), Py (0.5 mmol), solvent (8 mL), N₂ atmosphere, 70 °C, MW, 30 min. ² Yields of isolated products after column chromatographic. ³ Yield using 2-MeTHF as solvent under optimized conditions.