Table 2.
Mean difference (log10) in viral burden at Day 3 post infection in caudal lung, cranial lung, and turbinate tissues between groups receiving active galidesivir treatment and the vehicle control.
| Group | n | Mean (PFU/100 mg, log10) | Difference vs. Control | 95% CI for Treatment Difference | p-Value 1 | |
|---|---|---|---|---|---|---|
| Caudal lung | Group 1: 100 mg/kg BID (−24 h) | 4 | 4.86 | −1.53 | (−2.68, −0.38) | <0.05 |
| Group 2: 100 mg/kg BID (+1.5 h) | 4 | 4.42 | −1.97 | (−3.12, −0.81) | <0.05 | |
| Group 3: 100 mg/kg BID (+24 h) | 4 | 5.74 | −0.65 | (−1.80, 0.51) | NS | |
| Group 4: control | 4 | 6.39 | NA | NA | NA | |
| Cranial lung | Group 1: 100 mg/kg BID (−24 h) | 4 | 5.03 | −1.42 | (−2.22, −0.61) | <0.05 |
| Group 2: 100 mg/kg BID (+1.5 h) | 4 | 4.75 | −1.70 | (−2.50, −0.89) | <0.05 | |
| Group 3: 100 mg/kg BID (+24 h) | 4 | 5.68 | −0.77 | (−1.57, 0.04) | NS | |
| Group 4: control | 4 | 6.45 | NA | NA | NA | |
| Turbinates | Group 1: 100 mg/kg BID (−24 h) | 4 | 6.51 | −0.31 | (−1.47, 0.86) | NS |
| Group 2: 100 mg/kg BID (+1.5 h) | 4 | 5.96 | −0.85 | (−2.02, 0.31) | NS | |
| Group 3: 100 mg/kg BID (+24 h) | 4 | 6.83 | 0.01 | (−1.15, 1.18) | NS | |
| Group 4: control | 4 | 6.81 | NA | NA | NA |
1 Dunnett’s test for mean differences. CI, confidence interval; NA, not applicable; NS, not significant; PFU, Plaque Forming Units; BID, twice daily dosing.