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Effect of metformin and silymarin (MET+SM) combination therapy on (A) skeletal muscle and (B) adipose tissue insulin sensitivity expressed as basal and insulin-stimulated glycogenesis in hereditary hypertriglyceridaemic (HHTg) rats. Values are expressed as mean ± SEM; n = 6 for HHTg/C, n = 7 for HHTg/MET, n = 8 for HHTg/MET+SM; ††† p < 0.001 probability reflecting the effect of MET therapy vs. MET+SM combination therapy.
