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. 2022 Jan 17;15(2):682. doi: 10.3390/ma15020682

Table 8.

Comparison of BioNTech/Pfizer and Moderna vaccines based on mRNA and lipid nanoparticles.

BioNTech/Pfizer Moderna
Name of the medicinal product Comirnaty concentrate for dispersion for injection. COVID-19 mRNA vaccine (with modified nucleosides) COVID-19 Vaccine Moderna dispersion for injection. COVID-19 mRNA vaccine (with modified nucleosides)
List of excipients

  • lipids: ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(hexyl 2-decanoate), (ALC-0315) 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, (ALC-0159) 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)

  • cholesterol

  • potassium chloride

  • potassium dihydrogen phosphate

  • sodium chloride

  • disodium phosphate dihydrate

  • sucrose

  • water for injection

  • lipid SM-102

  • cholesterol

  • 1,2-distearyl-sn-glycero-3-phosphocholine (DSPC)

  • 1,2-dimethyl-rac-glycero-3-methoxypolyethylene glycol, molecular weight 2000 (PEG2000 DMG)

  • trometamol

  • trometamol hydrochloride

  • acetic acid

  • sodium acetate trihydrate

  • sucrose

  • water for injection
Ref. [170] [171]