Table 3.

The five elements of the outcomes

Domain	Specific measurement	Specific metric	Method of aggregation	Time-points
Primary outcome
Stable angina symptom score	Symptom score standard classification [22]	Difference between two groups	Proportion	Baseline, 28 days after treatment
Secondary outcomes
ECG parameters	Classification of 12-lead ECG improvement [23]	Difference between two groups	Proportion	Baseline, 28 days after treatment
SAQ scores	SAQ [24]	Difference in the change between groups	Mean/ median	Baseline, 28 days after treatment
Nitroglycerin consumption	Count	Compare the difference between groups	Median	Baseline, 28 days after treatment
Safety outcomes
Vital signs	Heart rate, respiration, body temperature, blood pressure	Compare the difference between groups	Mean/ median	Run-in period, baseline, 28 days after treatment
Clinical laboratory tests	Routine blood test, routine urinalysis, serum biochemistry, blood coagulation index, and fasting blood glucose	Compare the difference between groups	Mean/ median	Baseline, 28 days after treatment
AEs, SAEs	Common Terminology Criteria for AEs version 4.03.	Compare the difference between groups	Proportion	Baseline, 28 days after treatment

ECG electrocardiogram, SAQ Seattle Angina Questionnaire