Table 3.
Observer-reported outcomes, stratified by patient age.
| Observer-Reported Outcomes | Patient Age | Statistical Test | ||
|---|---|---|---|---|
| 2 Years (n = 61) |
3 Years (n = 60) |
4 Years (n = 61) |
||
| Result intake | ||||
| Fully taken | 55 (90) a | 55 (92) | 60 (98) | F b: p = 0.21 |
| Partly taken | 5 (8) | 5 (8) | 1 (2) | |
| Not taken | 1 (2) | 0 (0) | 0 (0) | |
| Patient reaction | ||||
| Positive | 7 (11) | 27 (45) | 31 (51) | χ2 c: p < 0.001 |
| Neutral | 36 (59) | 26 (43) | 29 (48) | |
| Negative | 18 (30) | 7 (12) | 1 (2) | |
| Preparation and administration time | ||||
| Short | 3 (5) | 5 (8) | 14 (23) | χ2: p < 0.001 |
| Medium | 36 (59) | 48 (80) | 47 (77) | |
| Long | 22 (36) | 7 (12) | 0 (0) | |
| Divided dose | ||||
| No divided dose | 50 (82) | 53 (88) | 60 (98) | χ2: p = 0.012 |
| Use divided dose | 11 (18) | 7 (12) | 1 (2) | |
| Food/drink d | ||||
| No food/drink | 35 (57) | 21 (35) | 39 (64) | χ2: p = 0.004 |
| Use food/drink | 26 (43) | 39 (65) | 22 (36) | |
| Alteration e | ||||
| No alteration | 43 (70) | 51 (85) | 58 (95) | χ2: p = 0.001 |
| Use alteration | 18 (30) | 9 (15) | 3 (5) | |
| Extra device f | ||||
| No extra device | 43 (70) | 51 (85) | 58 (95) | χ2: p = 0.001 |
| Use extra device | 18 (30) | 9 (15) | 3 (5) | |
| Reward | ||||
| No reward | 57 (93) | 57 (95) | 60 (98) | F: p = 0.44 |
| Use reward | 4 (7) | 3 (5) | 1 (2) | |
| Restraint | ||||
| No restraint | 61 (100) | 60 (100) | 61 (100) | |
| Use restraint | 0 (0) | 0 (0) | 0 (0) | |
a n (%): number and percentages; b F: Fisher’s exact test; c χ2: Pearson’s chi squared test; d either mixed with the drug or taken just before or after administration; e modification of dosage form prior to administration; f device not provided with the medicine.