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. 2022 Jan 21;21:27. doi: 10.1186/s12943-021-01486-5

Fig. 1.

Fig. 1

The affection of metabolic alterations on anti-tumor functions of CD8+ TILs. Metabolic alterations of CD8+ TILs mainly reflect in glycolysis and fatty acid metabolism. Reduced activity of enolase 1 and HK2 inhibits functions of CD8+ TILs through impairing glycolysis, whereas increased production of PEP promotes it. Compared with positive influence of fatty acid catabolism, fatty acid accumulation suppresses functions of CD8+ TILs. Components in Fig. 1 are drawn using tools in Biorender.com