Fig. 3.

Metabolic rewiring on anti-tumor functions of NK cells. Metabolic rewiring is critical to maintaining anti-tumor functions of NK cells. Inhibited mitochondrial respiration induces C-to-U RNA editing in NK cells to elevate fitness in the TME with hypoxia. MYC and SREBP engage in metabolic fitness of NK cells. MYC supports OXPHOS and glycolysis in NK cells through promoting expression of glycolytic enzymes and glucose transporters and increasing mitochondrial mass, finally inhibiting tumor progression. SREBP also promotes OXPHOS and glycolysis in NK cells. Based on this, inhibiting SREBP reduces generation of IFN-γ and expression of granzyme-B, finally impairing anti-tumor cytotoxicity of NK cells. Components in Fig. 3 are drawn using tools in Biorender.com