Table 1.

The synergy between targeting metabolism and existing anti-cancer therapies

Existing Anti-cancer Therapies	Metabolic Manipulation	Purpose Of Manipulation	Synergistic Mechanism	Reference
Adoptive transfer protocols of autologous T cells	Glucose analog 2-DG	Inhibiting glycolysis	Generation of T cells with memory phenotype	Sukumar et al .[129]
Oncolytic viruses	Engineering oncolytic viruses to express leptin	Increasing FAO and OXPHOS and promoting mitochondrial biogenesis	Differentiation of T cells into memory-like phenotype	Rivadeneira et al .[130]
Immune checkpoint blockade	Mitochondrial activators	Activating FAO and OXPHOS and promoting mitochondrial expansion	Enhanced activation and proliferation of CTLs	Chamoto et al .[131]