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. 2022 Jan 21;19:8. doi: 10.1186/s12989-022-00448-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7. — 3D micro-CT imaging following intratracheal instillation and how to view the CT image and the relationship between the CT image and the anatomical position. At 3 days: A control group. B 0.2 mg-exposure group. C 1.0 mg-exposure group. At 1 month: D control group. E 0.2 mg-exposure group. F 1.0 mg-exposure group. At 3 monthss: G control group. H 0.2 mg-exposure group. I 1.0 mg-exposure group. Diffuse or centrilobular infiltration (red arrow) in both lungs was presented at 3 days and 1 month after the exposure in a dose-dependent manner. The finding was persisted during 1 month and improved at 3 months after the exposure. The relationship between the CT image and the anatomical position is shown at J