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. 2022 Jan 21;15:3. doi: 10.1186/s13072-022-00437-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Methylation and Dlk1 expression levels in paternal sperm and the F1 generation of the mouse model. a Model of the CpG site in the IG-DMR at the Dlk1/Gtl2 locus in mouse. b Global DNA-methylation level (5-mC) in paternal sperm cells. c Expression level of Dlk1 in liver from 10-week-old F1 offspring. d Methylation levels of the IG-DMR in paternal sperm cells. e Methylation levels of IG-DMR in F2 liver cells. IG-DMR, intergenic differentially methylated region. M mean of 27 CpG sites. CON-M and CON-F male and female offspring of the CSE group; CSE-M and CSE-F male and female offspring of the CON group. *p < 0.05.**p < 0.01.***p < 0.001 compared to the CON group