Skip to main content
. 2022 Jan 5;14(1):127. doi: 10.3390/pharmaceutics14010127

Table 6.

Mathematical modelling and drug release kinetics from matrices (biorelevant dynamic dissolution).

Determination Coefficients for Mathematical Models
Higuchi Korsmeyer—Peppas Zero-Order First-Order Weibull Included Time
Interval (min)
Sample R 2 R 2 Release Exponent n R 2 R 2 R 2 b
M125 0.9655 0.9966 0.64 (0.61; 0.68) 0.8862 0.9889 0.9973 0.73 (0.62; 0.85) 240
M100 0.9669 0.9912 0.63 (0.57; 0.68) 0.8654 0.9722 0.9901 0.63 240
M75 0.9426 0.9931 0.70 (0.64; 0.76) 0.9243 0.9906 0.9935 0.81 (0.62; 0.99) 240
N125 0.9685 0.9884 0.61 (0.55; 0.68) 0.8450 0.9873 0.9920 0.80 (0.62; 0.97) 240
N100 0.9336 0.9962 0.73 (0.69; 0.78) 0.9463 0.9891 0.9957 0.73 240
N75 0.9356 0.9949 0.72 (0.67; 0.78) 0.9393 0.9885 0.9949 0.72 240
N75M50 0.9530 0.9967 0.68 (0.64; 0.72) 0.9145 0.9931 0.9969 0.79 (0.69; 0.90) 240
N50M50 0.9499 0.9943 0.68 (0.63; 0.73) 0.9135 0.9942 0.9967 0.84 (0.71; 0.97) 240
N25M50 0.9569 0.9925 0.66 (0.60; 0.72) 0.8948 0.9875 0.9930 0.76 (0.58; 0.95) 240