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. 2022 Jan 4;14(1):120. doi: 10.3390/pharmaceutics14010120

Table 1.

Clinical trials of photodynamic therapy-based combination strategies.

Phase Photosensitizer Combined Interventions Cancer Type Status Years of Study Clinical Trial Reference Number
Phase I Temoporfin (Foscan®) Surgery Non-small-cell lung cancer Completed 2013–2019 NCT01854684
HPPH (Photochlor®) Surgery Head and neck cancer Completed 2007–2018 NCT00470496
HPPH (Photochlor®) Surgery (laser therapy) Primary or invasive larynx cancer Completed 2008–2018 NCT00675233
Motexafin lutetium Surgery Cervical intraepithelial neoplasia Terminated 2003–2013 NCT00005808
- (Not marked) Surgery and radiosensitizer (etanidazole) Intraperitoneal or pleural cancer Terminated 2003–2013 NCT00028782
Porfimer sodium (Photofrin®) Surgery Malignant mesothelioma Completed 2003–2011 NCT00054002
Hematoporphyrin derivative Radiotherapy (brachytherapy) Lung cancer Completed 2004–2013 NCT00014066
Hexaminolevulinate (HAL) Placebo ointment Cervical intraepithelial neoplasia Completed 2010–2016 NCT01256424
Aminolaevulinic acid (ALA) Adjuvant (vitamin D3) Pre-malignant anal tumor Recruiting 2016– NCT02698293
Porfimer sodium (Photofrin®) Chemotherapy (gemcitabine hydrochloride) Advanced pancreatic cancer Completed 2013–2018 NCT01770132
Phase II Aminolaevulinic acid (ALA) Surgery Superficial non-melanoma skin cancer Completed 2003–2013 NCT00002963
Porfimer sodium (Photofrin®) Surgery and chemotherapy Non-small-cell lung cancer Terminated 2008–2020 NCT00601848
Porfimer sodium (Photofrin®) Surgery and chemotherapy (cisplatin) Malignant pleural mesothelioma Completed 2016–2018 NCT02662504
Porfimer sodium (Photofrin®) Surgery and chemotherapy Malignant pleural mesothelioma Recruiting 2014– NCT02153229
Hexaminolevulinate (HAL) Placebo Cervical intraepithelial neoplasia Terminated 2008–2013 NCT00708942
Aminolaevulinic acid (ALA) Placebo Cervical intraepithelial neoplasia Completed 2015–2019 NCT02631863
Phase II/III Methyl-5-aminolevulinate hydrochloride (Metvix®) Surgery (Ablative CO2 laser) Basal cell carcinoma Completed 2010–2015 NCT01260987
Phase III Porfimer sodium (Photofrin®) Chemotherapy (gemcitabine/cisplatin) Cholangiocarcinoma Terminated 2014–2019 NCT02082522
Porfimer sodium (Photofrin®) Chemotherapy (S-1) Cholangiocarcinoma Completed 2009–2014 NCT00869635
Methyl-5-aminolevulinate hydrochloride (Metvix®) Placebo cream Basal cell carcinoma Completed 2007–2010 NCT00472108
Methyl-5-aminolevulinate hydrochloride (Metvix®) Cryotherapy Basal cell carcinoma Completed 2007–2010 NCT00469417