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. 2022 Jan 8;27(2):392. doi: 10.3390/molecules27020392

Figure 1.

Figure 1

Mechanism of selenium-related bone metabolism. Selenium supplement encourages the activity of GPx and TrxR, and GPx activity is more activated in those with a selenium-deficient status. GPx and TrxR suppress NFκB activation at supranutritional selenium levels and regulate osteoclastogenesis and osteoblastogenesis. Co-treatment of 1α,25(OH)2D3 and selenium synergistically elevates TrxR1 protein and activity. GPxs: glutathione peroxidases; TrxRs: thioredoxin reductases; RANK: receptor activator of NFκB; RANKL: receptor activator of NFκB ligand.