. 2021 Dec 31;14(1):69. doi: 10.3390/v14010069

Table 8.

In vivo PK parameters in rats of the two most active inhibitors, NBCoV1 and NBCoV2.

Parameters ^a	NBCoV1		NBCoV2		UNITS
Parameters ^a	PO	IV	PO	IV	UNITS
Dose	10	5	10	5	mg/kg
t_1/2	11.32	3.57	3.96	3.52	h
T_max	2	0.25	4	2	h
C_max	1499.76	7815.76	30.12	2219.45	ng/mL
C₀	-	7407.25	-	1710.87	ng/mL
AUC_0-t	12,023.00	37,515.91	318.78	18,074.45	ng/mL ∗ h
MRT_{0-inf_obs}	14.34	4.02	7.28	5.09	h
CL_obs	-	0.00013	-	0.00027	(mg/kg)/(ng/mL)/h
Vss__obs	-	0.00053	-	0.00140	(mg/kg)/(ng/mL)
Vz/F__obs	0.01078	-	0.17593	-	(mg/kg)/(ng/mL)
CL/F__obs	0.00066	-	0.03082	-	(mg/kg)/(ng/mL)/h
F%	20.1	-	0.9	-	100 ∗ AUC(PO)/AUC(IV)

^a A single oral (PO) or IV dose; t_1/2, apparent terminal elimination half-life; t_max, time to peak concentration; C_max, maximum measured plasma concentration; C₀, initial measured plasma concentration; AUC, area under the concentration time curve; MRT, mean residence time; CL, clearance rate of the analyte (IV only); V_ss, volume of distribution of the analyte in the test system estimated at steady state (IV only); VZ/F, apparent volume of distribution; CL/F, apparent oral clearance; F%, bioavailability, represents the fraction of a dose reaching systemic circulation intact; i.e., fraction of dose absorbed.