Table 2.

Assessment of the quality of the included studies.

Study (Year)	Risk of Bias				Applicability Concerns
	Patient Selection	Index Test	Reference Standard	Flow and Timing	Patient Selection	Index Test	Reference Standard
Wakasugi et al. [14]. (2008)	-	-	?	?	+	+	+
Momosaki et al. [15]. (2013)	-	+	?	+	+	+	+
McCullough et al. [16]. (2005)	+	+	+	+	+	+	+
Suiter et al. [17]. (2008)	?	-	+	-	+	+	+
Zhou et al. [18]. (2011)	?	-	-	?	+	+	+
Patterson et al. [19]. (2011)	?	+	-	?	+	+	+
Hey et al. [20]. (2013)	?	+	+	+	+	+	+
Somasundaram et al. [21]. (2014)	+	+	?	?	+	+	+
Hassan et al. [22]. (2014)	?	+	-	?	+	+	+
Mann et al. [23]. (2000)	+	+	+	?	+	+	+
Gonzá-lez-Fernández et al. [24]. (2011	+	-	+	?	+	+	+
Antonios et al. [25]. (2010)	+	-	+	+	+	+	+
Trapl et al. [26]. (2007)	+	+	+	+	+	+	+
Warnecke et al. [27]. (2017)	+	+	+	+	+	+	+
Said Bas-siouny et al. [28]. (2017)	?	+	+	?	+	+	+

(+): Low Risk, (-): High Risk, (?): Unclear Risk. The risk of bias and applicability were assessed according to QUADAS-2 (www.quadas.org, accessed on 12 December 2021).