. Author manuscript; available in PMC: 2022 Sep 1.

Published in final edited form as: J Pediatr Gastroenterol Nutr. 2021 Sep 1;73(3):395–402. doi: 10.1097/MPG.0000000000003173

Table 2:

Association of Risk Factors with GI-related Admissions

Potential Associated Risk Factor		Total number n (%) n=231	Participants with GI-related Hospitalization n (%) n=21	Participants with no GI-related Hospitalization n (%) n=210	p value
Phenotypic characteristics
Genotype	F508del/F508del	132 (57.1)	12 (57.1)	120 (57.1)	0.94 ^a
	F508del/other	84 (36.4)	8 (38.1)	76 (36.2)	0.94 ^a
	Other/other	15 (6.5)	1 (4.8)	14 (6.7)
Meconium ileus	Yes	27 (11.7)	3 (14.3)	24 (11.4)	0.72 ^b
Meconium ileus	No	204 (88.3)	18 (85.7)	186 (88.6)	0.72 ^b
Choice of feeding
Feeding Type closest to enrollment^* (n=229)	Breastfeeding ONLY	66 (28.7)	7 (33.3)	59 (28.2)	0.17 ^a
	Formula ONLY	117 (50.9)	13 (61.9)	104 (49.8)
	Both	47 (20.4)	1 (4.8)	46 (22.0)
Medications
PERT dose at/near enrollment (PI infants only, n=210)	Normal (</=2000 LU/kg/meal)	164 (78.1)	13 (65.0)	151 (79.5)	0.16 ^b
PERT dose at/near enrollment (PI infants only, n=210)	High (>2000 LU/kg/meal)	46 (21.9)	7 (35.0)	39 (20.5)	0.16 ^b
Acid suppressant (some infants took >1 during study period)	Never Taken	78 (33.8)	0 (0.0)	78 (37.1)	<0.001 ^a
	Ever Taken	153 (66.2)	21 (100)	132 (62.9)	<0.001 ^a
	H2 receptor antagonist	116 (75.8)
	Proton pump inhibitor	85 (55.5)
Antibiotic use	Never Taken	55 (23.8)	5 (23.8)	50 (23.8)	1.00 ^a
Antibiotic use	Ever Taken	176 (76.2)	16 (76.2)	160 (76.2)	1.00 ^a
Stool markers
Calprotectin level at enrollment^* (n=216)	Normal (<200 μg/g)	135 (62.2)	8 (40.0)	127 (64.5)	0.03 ^a
Calprotectin level at enrollment^* (n=216)	High (>=200 μg/g)	82 (37.8)	12 (60.0)	70 (35.5)	0.03 ^a
Relative abundance of K. pneumoniae in the fecal microbiota at enrollment^* (n=193)	Normal (<1%)	143 (74.1)	8 (44.4)	135 (77.1)	< 0.01 ^b
	High (>=1%)	50 (25.9)	10 (55.6)	40 (22.9)	< 0.01 ^b

^a.

Chi square test

^b.

Fisher’s Exact test

Data not available for all subjects (see text)