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. 2021 Aug 10;7(1):e10243. doi: 10.1002/btm2.10243

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© 2021 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(a) The two components of the MucoJet are clicked together by the user prior to administration. The polymeric membrane is then dissolved. Water contact with the chemical propellant causes a chemical reaction that produces carbon dioxide gas, inducing a sufficient jet velocity and pressure for the vaccine solution to penetrate the buccal mucosa layer. (b) The MucoJet is delivered by mouth to buccal tissue (left). Upon penetration through the mucosal layer, the vaccine solution is delivered to antigen‐presenting cells (APCs) in the mucosa‐associated lymphoid tissue (MALT) to generate an immune response (right) Source: Reprinted/adapted from Aran et al. Sci Transl Med. 2017;9(380):eaaf6413. © The Authors, some rights reserved, exclusive licensee AAAS. Distributed under a CC BY‐NC 4.0 license http://creativecommons.org/licenses/by‐nc/4.0/