FIGURE 7.

Predicted protein–protein interaction network of fibronectin–integrin signaling molecules and osteoclast differentiation markers. Genes encoding fibronectin–integrin signaling molecules include Itgb3, Itba5, Fn1, Pxn, Ptk2, Prkca, and RhoA, as verified by this study. Osteoclast differentiation markers include the downregulated profile (Nfatc1, Ctsk, DC‐stamp, Rela, Camk2a, Traf6, Mmp9, and Acp5) verified in Figure 3. The connection edges shown are of high confidence (0.700), with the thicker connection line indicating the highest confidence (0.900). The network proteins were clustered into two groups using the k‐means method