Figure 1.

Identification of IgG-specific B-cell epitopes on the spike (S), nucleocapsid (N), membrane (M) and ORF8 proteins. We pooled 50 pre-pandemic plasma samples collected before January 2018 to constitute a COVID-19 negative control (Pool COVID−). We used 50 plasma samples from patients tested positive for SARS-CoV-2 by RT-PCR, collected between 25 and 35 days after the onset of symptom, to evaluate IgG reactivity to 60 peptides. OD results are represented for each sample as a pink point for COVID+ samples. The red line represents the mean OD for COVID+ patients and the blue line represents the mean OD of 50 repeated measures for the COVID− pool. * indicates the peptides selected for further analysis.