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. 2022 Jan 21;29:5. doi: 10.1186/s12929-022-00788-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Histologic analysis of DBPR114 and sorafenib treatment in human HCC xenograft tumors. A and B Effect on cell proliferation (Ki-67 staining) and C and D effect on vascular endothelial cells (CD31 staining) in Huh7 and HA22T/VGH xenograft tumors. Tumor tissues were formalin-fixed and paraffin-embedded, with the paraffin sections used for immunohistochemical staining. Digital scans were performed with a 3DHITECH PANNORAMIC Midi slide scanner, and images were captured with PANNORAMIC Viewer software. Representative images were extracted from two separate animals in each group at × 40 magnification. Red arrows indicate apoptotic cell death and multinucleated cells. Bar: 50 µm