Table 3.

Human gene sets significantly downregulated by DBPR114

Gene set	Size	p value	FDR	Description	Reference
HALLMARK_G2M_CHEKPOINT	190	0.000	0.000	Genes involved in the G2/M checkpoint that progress through the cell division cycle	MSigDB v5.0
HALLMARK_MITOTIC_SPINDLE	197	0.001	0.001	Genes essential for mitotic spindle assembly	MSigDB v5.0
HALLMARK_E2F_TARGETS	195	0.003	0.002	Genes encoding cell cycle–related targets of E2F transcription factors	MSigDB v5.0
HALLMARK_MTORC_SIGNALING	195	0.001	0.005	Genes upregulated through activation of mTOR complex 1	MSigDB v5.0

Gene set enrichment analysis was performed on Huh7 xenograft tumors (FDR < 0.05). The Huh7 tumors from the vehicle control and treated groups were harvested at the end of studies (Fig. 4). The tumor RNA was isolated and analyzed for human gene expressions through mRNA sequencing