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. 2021 Dec 28;12(1):38. doi: 10.3390/membranes12010038

Figure 2.

Figure 2

Volume-regulated anion channel (VRAC) is involved in multi drug resistance in two ways. On the one hand, through VRAC containing the LRRC8D subunit, platinum-based anti-cancer chemicals such as cisplatin and carboplatin enter the cell, which then induces apoptosis. On the other hand, VRAC, through the release of chlorides and organic osmolytes from the cell, participates in apoptosis volume decrease (AVD), which is associated with the occurrence of apoptosis in many types of tumor cells [43,47,48].