Figure 3.

The schematic representation of the volume-regulated anion channel (VRAC). VRACs are heteromers composed of subunits belonging to the LRRC8 family. The main component is the leucine-rich 8A repeat that forms the LRRC8A. This subunit is accompanied by four homologous subunits that belong to the group LRRC8B-LRRC8E, and the channel properties depend on the type of these subunits. The connection of LRRC8A with LRRC8D (right-hand channel) is particularly important. It determines the formation of a VRAC with a relatively large diameter, allowing larger molecules such as cisplatin, blasticidin S, and oxaliplatin to pass through this channel into the cell interior. VRACs that lack the LRRC8D subunit (left channel) have a smaller diameter and transport smaller molecules. LRRC8A/C and LRRC8A/E pairs transport cisplatin only in a marginal manner [26,93].