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. 2022 Jan 6;11(2):295. doi: 10.3390/jcm11020295

Figure 3.

Figure 3

Comparison of saliva MS spectra between SARS-CoV-2(+) (n = 105) and control (n = 51) groups sampled at D0. Mean MS spectra profiles with a total-ion-current normalization applied to peak spectra intensities of Cov+ (A) and Cov− (B) individuals and their superposition (C). (D) List of MS peaks with significant total-ion-current normalized intensity differences (two-tailed Wilcoxon rank sum test (p < 0.05) with a Benjamini–Hochberg correction (p < 0.1) for each peak) between Cov+ and Cov− groups. Dashed box highlighted the most two relevant peaks. (E) Summary table of Wilcoxon rank sum tests with a Benjamini–Hochberg (BH) correction for each peak. Ratio represent the proportion (%) of mean peak intensity variations between Cov+ and Cov− groups. Positive and negative values correspond, respectively, to upper and lower mean peak intensity variations in Cov+ compared to Cov− groups. Comparison of the two greatest peaks at m/z 2489.2 (F) and at m/z 5418.9 (G) differentiating Cov+ and Cov− groups. Lines and shadow represent mean values ± interquartile range (IQR), respectively. Dashed box framed each relevant peak. PCA (H) and UMAP (I) performed on Cov+ (n = 105) and Cov− (n = 51) groups using the selected peaks (n = 9) with two-tailed Wilcoxon rank sum test (p < 0.05) and a Benjamini–Hochberg correction (p < 0.1).