Table 2.
Gene Ontology and KEGG pathway analysis of upregulated proteins in Hacl1−/− mouse kidney.
| p-Value | Genes | |
|---|---|---|
| GO Biological Process | ||
| Fatty acid metabolic process | 2.60 × 10−3 | Acsl3, Crot, Hsd17b4 |
| Lipid metabolic process | 2.10 × 10−2 | Acsl3, Crot, Hsd17b4 |
| Fatty acid beta-oxidation | 2.20 × 10−2 | Crot, Hsd17b4 |
| GO Cellular Compartment | ||
| Peroxisome | 6.00 × 10−7 | Acsl3, Crot, Hsd17b4, Scp2, Zadh2 |
| Intracellular membrane-bounded organelle | 7.30 × 10−3 | Acsl3, Crot, Hsd17b4, Scp2 |
| Mitochondrion | 1.20 × 10−2 | Acsl3, Crot, Hsd17b4, Scp2, Zadh2 |
| Peroxisomal membrane | 2.90 × 10−2 | Acsl3, Hsd17b4 |
| GO Molecular Function | ||
| Receptor binding | 1.40 × 10−2 | Crot, Hsd17b4, Scp2 |
| Actin filament binding | 5.90 × 10−2 | Myo1b, Svil |
| Transferase activity, transferring acyl groups | 7.40 × 10−2 | Crot, Scp2 |
| KEGG Pathway | ||
| Peroxisome | 1.20 × 10−6 | Acsl3, Crot, Hsd17b4, Scp2 |
| Primary bile acid biosynthesis | 6.20 × 10−3 | Hsd17b4, Scp2 |
| PPAR signaling pathway | 3.10 × 10−2 | Acsl3, Scp2 |
| Metabolic pathways | 7.30 × 10−2 | Acsl3, Hsd17b4, Scp2 |