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. 2022 Jan 20;22:17. doi: 10.1186/s12906-021-03477-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Mincle is the key to A&P to improve mesangial cell damage by down-regulating macrophage inflammation. a, The mRNA expression of Mincle in BMDM cells detected by Real-time PCR analysis. b-d, The protein level of Mincle in BMDM cells detected by western boltting analysis. e-g, The mRNA expression of TNF-α, IL-1β and IL-6 in co-culture cells detected by Real-time PCR analysis. h-l, The protein level of p-NFκB, TNF-α, IL-1β and IL-6 in co-culture cells detected by western boltting analysis. (The data are expressed as the mean ± SD. Compared with Control group, *P < 0.01. Compared with HG group, ^#P < 0.05, **P < 0.05. Compared with HG + A&P group, ^##P < 0.05)