Table 1.
Sociodemographic and clinical characteristics of PLHIV according with level of disease and treatment burden.
| Characteristics | L-TBD (n = 432; 81.3%) |
H-TDB (n = 99; 18.6%) |
p-Value | Total |
|---|---|---|---|---|
| Age, years, median (IQR) | 50 (41–57) | 44 (34–53) | <0.001 | 49 (39–56) |
| Sex *, Male, n (%) | 375 (86.8) | 87 (87.9) | 0.775 | 462 (87.0) |
| Education, n (%) | 0.109 | |||
| Middle/High School | 254 (58.8) | 50 (50.5) | 304 (57.2) | |
| University/Master | 176 (40.7) | 47 (47.5) | 223 (42.0) | |
| Other/Unknown | 2 (0.5) | 2 (2.0) | 4 (0.7) | |
| Job, n (%) | 0.102 | |||
| Stable work | 272 (62.9) | 52 (52.5) | 324 (60.0) | |
| Not stable work | 55 (12.7) | 15 (15.1) | 70 (13.2) | |
| Not working | 44 (10.2) | 18 (18.2) | 62 (11.7) | |
| Other/Unknown/Retired | 61 (14.1) | 14 (14.1) | 75 (14.1) | |
| Italy Born, n (%) | 406 (94.0) | 92 (92.9) | 0.696 | 498 (93.8) |
| Year HIV Diagnosis, n (%) | 0.178 | |||
| <2001 | 106 (24.5) | 23 (23.2) | 129 (24.3) | |
| 2001–2010 | 114 (26.4) | 18 (18.2) | 132 (24.9) | |
| 2011–2015 | 108 (25) | 25 (25.2) | 133 (25) | |
| >2015 | 104 (24.1) | 33 (33.3) | 137 (25.8) | |
| Year first ARV start, n (%) | 0.137 | |||
| <2001 | 89 (20.6) | 17 (17.17) | 106 (19.9) | |
| 2001–2010 | 109 (25.23) | 17 (17.17) | 126 (23.7) | |
| 2011–2015 | 116 (26.85) | 28 (28.28) | 144 (27.1) | |
| >2015 | 118 (27.31) | 37 (37.37) | 155 (29.2) | |
|
Mode of HIV
transmission, n (%) |
0.194 | |||
| Homosexual Contacts | 274 (63.4) | 52 (52.5) | 326 (61.4) | |
| Heterosexual Contacts | 31 (7.2) | 7 (7.1) | 38 (7.2) | |
| Sexual contacts (mode not specified) | 88 (20.4) | 27 (27.3) | 115 (21.7) | |
| Other not-sexual mode | 39 (9.0) | 13 (13.1) | 52 (9.8) | |
|
Current HIV-RNA,
copies/mL, n (%) |
0.044 | |||
| <50 copiess/mL | 388 (89.8) | 80 (80.8) | 468 (88.1) | |
| ≥50 copies/mL | 19 (4.4) | 8 (8.1) | 27 (5.1) | |
| unknown/not reported | 25 (5.8) | 11 (11.1) | 36 (6.8) | |
| Current CD4, cells/mmc, n (%) | 0.463 | |||
| <200 cells/mmc | 39 (9.0) | 12 (12.12) | 51 (9.6) | |
| 200–500 cells/mmc | 87 (20.14) | 18 (18.18) | 105 (19.8) | |
| >500 cells/mmc | 251 (58.1) | 52 (52.53) | 303 (57.1) | |
| unknown/not reported | 55 (12.73) | 17 (17.17) | 72 (13.6) | |
| Current Regimen (R), n (%) | 0.011 | |||
| 2 ARV R STR | 85 (19.68) | 13 (13.13) | 98 (18.46) | |
| 3 ARV R STR (w/o booster) | 203 (46.99) | 46 (46.46) | 249 (46.9) | |
| 3 ARV R STR (with booster) | 32 (7.41) | 14 (14.14) | 46 (8.66) | |
| 2 ARV R MTR | 58 (13.43) | 8 (8.08) | 66 (12.4) | |
| 3 ARV R MTR | 37 (8.56) | 7 (7.07) | 44 (8.3) | |
| Unknown | 17 (3.9) | 11 (11.1) | 28 (5.3) | |
| STR, n (%) | 320 (77.1) | 73 (82.9) | 0.228 | 393 (78.1) |
| Treatment Satisfaction, n (%) | 0.007 | |||
| Yes, fully | 243 (56.25) | 26 (26.26) | 269 (50.66) | |
| Yes, but can be improved | 180 (41.67) | 61 (61.62) | 241 (45.39) | |
| No, I’ve some issues | 9 (2.08) | 7 (7.07) | 16 (3.01) | |
| Not at all | 0 (0.0) | 2 (2.02) | 2 (0.38) | |
| Other/Unknown | 0 (0.0) | 3 (3.0) | 3 (0.6) | |
| Number of daily assumption of all the drugs > 1, n (%) | 106 (24.5) | 26 (26.3) | 0.72 | 132 (24.9) |
| Polypharmacy, ≥5 drugs/day, n (%) | 75 (17.4) | 18 (18.2) | 0.846 | 93 (17.5) |
| Physical Health, (1–5 scale), median (IQR) | 2 (1–3) | 3 (2–3) | <0.001 | 2 (1–3) |
| Mental Health, (1–5 scale), median (IQR) | 2 (1–3) | 3 (2–4) | <0.001 | 2 (2–3) |
| Sexual Health, (1–5 scale), median (IQR) | 3 (2–4) | 4 (3–5) | <0.001 | 3 (3–5) |
| Overall Health, (1–5 scale), median (IQR) | 2 (2–3) | 3 (2–3) | <0.001 | 2 (2–3) |
Abbreviations: 2 ARV R (2-drug antiretroviral regimen), 3 ARV R (3-drug antiretroviral regimen), STR (single tablet regimen), MTR (multiple tablet regimen), w/o (without). * Sex at birth.