Figure 3.

Platelet RNA splicing principal component groups have distinct clot formation and platelet aggregation responses. (A) Compared with group 1 (healthy donors, controls), group 3, and to a lesser extent group 2, had prolonged CFT, decreased α angle and decreased MCF by ROTEM. (B) Compared with group 1 (healthy donors, controls), group 2 had decreased platelet aggregation responses to Adenosine diphosphate, thrombin analog, and collagen stimulation by platelet aggregometry. Kruskal-Wallis tests were used to assess overall statistical significance and Wilcoxon signed rank tests were used to make pairwise comparisons; N.S., not statistically significant; *p ≤ 0.05. ROTEM, rotational thromboelastometry.