Table 2.
The IC50 values (mean ± SD)a of 35a and 35b binding toward other S1PRs.
| Compd. | IC50 (nM) |
||||
|---|---|---|---|---|---|
| S1PR1 | S1PR2 | S1PR3 | S1PR4 | S1PR5 | |
| JTE-013 | >1000 | 58.4 ± 7.4 | >1000 | ND | ND |
| S1P | 1.4 ± 0.3 | 3.6 ± 0.5 | 0.4 ± 0.2 | 151 ± 82 | 3.1 ± 1.1 |
| 35a | >1000 | 29.1 ± 2.6 | >1000 | >1000 | >1000 |
| 35b | >1000 | 56.5 ± 4.0 | >1000 | >1000 | >1000 |
a
IC50 values were determined at least two independent experiments, each run was performed in duplicate; for compounds with IC50 < 100 nM, at least three independent experiments were performed, each run was performed in duplicate, ND-not determined.