Table 1.
ANKL | NTNKL | IVNKTL | |
---|---|---|---|
Sex | Male = female | Male > female | Male > female |
Median age | 40 years | 62 years | 46 years |
Ethnicity | Asian | Asian | Asian and Latin American |
Localization | PB, BM, liver, spleen | Systemic nodal | Intravascular growth |
Pathologic characteristics | Leukemic cells, from normal to highly atypical features CD3+, CD56+, cytotoxic molecules+, EBER+ |
High-grade morphology with centroblastoid appearance CD3+, CD8+, CD56−, cytotoxic molecules+, EBER+ |
Intraluminal large atypical cells CD3+, CD56+, cytotoxic molecules+, EBER+ |
Clinical course | Aggressive | Aggressive | Aggressive |
ANKL, aggressive NK cell leukemia; NTNKL, nodal T-/NK cell lymphoma; IVNKTL, intravascular NK/T-cell lymphoma; PB, peripheral blood; BM, bone marrow.