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. 2022 Jan 5;12(1):73. doi: 10.3390/life12010073

Table 1.

Other EBV-positive NK/T-cell malignancies of adult.

ANKL NTNKL IVNKTL
Sex Male = female Male > female Male > female
Median age 40 years 62 years 46 years
Ethnicity Asian Asian Asian and Latin American
Localization PB, BM, liver, spleen Systemic nodal Intravascular growth
Pathologic characteristics Leukemic cells, from normal to highly atypical features
CD3+, CD56+, cytotoxic molecules+, EBER+
High-grade morphology with centroblastoid appearance
CD3+, CD8+, CD56−, cytotoxic molecules+, EBER+
Intraluminal large atypical cells
CD3+, CD56+, cytotoxic molecules+, EBER+
Clinical course Aggressive Aggressive Aggressive

ANKL, aggressive NK cell leukemia; NTNKL, nodal T-/NK cell lymphoma; IVNKTL, intravascular NK/T-cell lymphoma; PB, peripheral blood; BM, bone marrow.