Table 1.

RCC Trials by Clinical Phase.

Trial	Therapies Evaluated	Clinical Trial Phase
Motzer et al., 2007 [9]	sunitinib vs. interferon alfa	Phase 3
Motzer et al., 2018 (CheckMate 214) [24]	ipilimumab + nivolumab vs. sunitinib	Phase 3
Rini et al., 2019 (IMmotion 151) [13]	bevacizumab + atezolizumab vs. sunitinib	Phase 3
Motzer et al., 2019 (JAVELIN Renal 101) [14]	axitinib + avelumab vs. sunitinib	Phase 3
Rini et al., 2019 (KEYNOTE-426) [13]	axitinib + pembrolizumab vs. sunitinib	Phase 3
Choueiri et al., 2021 (CheckMate 9ER) [16]	nivolumab + cabozantinib vs. sunitinib	Phase 3
Motzer et al., 2021 (CLEAR) [15]	lenvatinib + pembrolizumab vs. lenvatinib + everolimus vs. sunitinib	Phase 3