Table 2.
Section A: Patient Characteristics Stratified by Cohort (Athens vs Copenhagen) and Section B: Athens Affective/Nonaffective Status
| A) Athens vs Copenhagen | Descriptive Statistic | Athens N = 179 | Copenhagen N =101 | Athens vs Copenhagen P-value* |
|---|---|---|---|---|
| Age (n = 277) | Mean (SD) | 25.8 (7.5) | 23.8 (5.4) | .01 |
| Gender (n = 280) | N (%) | 120 (67%) | 53 (52% | .02 |
| Education (years) (n = 234) | Mean (SD) | 13.6 (2.5) | 12.1 (2.3) | <.01 |
| GAF baseline (n = 249) | Mean (SD) | 41.9 (15.8) | 37.5 (7.5) | .01 |
| PSP baseline total score (n = 189) | Mean (SD) | 38.3 (16.1) | 48.5 (13.1) | <.01 |
| DUP (n = 220) | Mean (SD) | 32.8 (59.8) | 116 (219.3) | .01 |
| PANSS total (n = 280) | Mean (SD) | 99.4 (23.8) | 76.1 (15.1) | <.01 |
| PANSS negative total (n = 280) | Mean (SD) | 21.1 (9.7) | 19.4 (6.3) | .07 |
| Remission (n = 280) | N (%) | 102 (57%) | 31 (31%) | <.01 |
| Cannabis (n = 278) | N (%) | 93 (53%) | 4 (4%) | <.01 |
| Stimulant (n = 279) | N (%) | 20 (11%) | 0 (0%) | <.01 |
| Opioid (n = 269) | N (%) | 1 (1%) | 0 (0%) | .44 |
| Hallucinogens (n = 271) | N (%) | 11 (6%) | 0 (0%) | .01 |
| Tobacco (n = 280) | N (%) | 97 (54%) | 13 (13%) | <.01 |
| B) Affective vs Nonaffective | Descriptive Statistic | Affective N =32 | Nonaffective N =133 | Affective vs Nonaffective P-value* |
| Age (n = 162) | Mean (SD) | 25.2 (7.2) | 25.9 (7.6) | .83 |
| Gender, male (n = 165) | N (%) | 14 (44%) | 94 (71%) | .03 |
| Education (years) (n = 162) | Mean (SD) | 13.9 (2.5) | 13.5 (2.5) | .75 |
| GAF baseline (n = 138) | Mean (SD) | 40.4 (15.8) | 41.4 (15.6) | .90 |
| PSP baseline total score (n = 124) | Mean (SD) | 33.6 (13.6) | 38.2 (15.6) | .35 |
| DUP (n = 157) | Mean (SD) | 19.7 (48.8) | 37.1 (63.6) | .26 |
| DUI (n = 137) | Mean (SD) | 63.9 (181.4) | 59.2 (80.6) | .90 |
| PANSS total (n = 165) | Mean (SD) | 89 (18.9) | 101.4 (24.3) | .02 |
| PANSS positive total (n = 165) | Mean (SD) | 28.7 (7.6) | 28.4 (6.8) | 090 |
| PANSS negative total (n = 165) | Mean (SD) | 14.8 (6.5) | 22.5 (9.7) | <.01 |
| PANSS general total (n = 165) | Mean (SD) | 45.5 (10.8) | 50.6 (14.1) | .09 |
| Remission (n = 165) | N (%) | 26 (81%) | 69 (52%) | .03 |
| Cohabitants (n = 161) | Mean (SD) | 2.2 (2) | 2.5 (2) | .81 |
| HAM total (n = 127) | Mean (SD) | 16 (10.5) | 17.2 (9.4) | .83 |
| YMRS total (n = 126) | Mean (SD) | 21.2 (14.7) | 13.2 (9.6) | .08 |
| Antipsychotic use prior to entry, yes (n = 165) | N (%) | 10 (31%) | 53 (40%) | .53 |
| Currently living alone, yes (n = 147) | N (%) | 7 (23%) | 22 (19%) | .71 |
| Currently unemployed, yes (n = 165) | N (%) | 7 (22%) | 43 (32%) | .46 |
| Lifetime cannabis use, yes (n = 16) | N (%) | 19 (61%) | 63 (48%) | .38 |
| Cannabis use in the past month, yes (n = 154) | N (%) | 10 (36%) | 28 (22%) | .35 |
| Stimulant use last 12 months, yes (n = 164) | N (%) | 5 (16%) | 13 (10%) | .53 |
| Opioid use last 12 months, yes (n = 154) | N (%) | 0 (0%) | 1 (1%) | .71 |
| Hallucinogen use last 12 months, yes (n = 156) | N (%) | 5 (16%) | 6 (5%) | .12 |
| Tobacco use last 12 months, yes (n = 165) | N (%) | 18 (56%) | 71 (53%) | .77 |
| Alcohol use >14 units per week, yes (n = 165) | N (%) | 2 (6%) | 2 (2%) | .35 |
| CGI severity of illness: 3/4/5/6/7 (n = 158) | Median (IQR) | 6 (5–7) | 6 (5–7) | .71 |
*Calculated using Welches t-test for continuous variables and chi-square tests for categorical variables. All P-values were FDR corrected using the Benjamini and Hochberg method. For substance use, any use in the last 12 months regardless of frequency.