Table 2.

Plasma BAFF and APRIL in the Full Sample Comprised by Diagnostic Groups and Healthy Controls Adjusting for Age and Sex

Cytokines	SCZ (n = 1123)	BIP (n = 846)	MDD (n = 40)	HC (n = 1212)	Group Comparison
BAFF, median (CI)	234 [228;241]	241 [233;249]	240 [227; 283]	235 [227;240]	BIP>SCZ,BIP>HC
APRIL, mean (CI)	281 [269;292]	259 [247;270]	260 [203;332]	335 [323;347]	HC>ALL,HC>SCZ,HC>BIP

SCZ, schizophrenia and other nonaffective psychotic disorders; BIP, bipolar spectrum disorder; MDD, major depressive disorder; HC, healthy control participants; ALL, all diagnostic groups; Plasma BAFF, B cell activating factor belonging to the TNF Family’, presented with the units pg/ml; CI, confidence interval. Data analysis based on transformed data (reciprocal transformation). BAFF is presented using back-transformed median with estimated confidence intervals based on empirical centiles in parenthesis. Plasma APRIL, a proliferation-inducing ligand, presented with the units pg/ml. Data analysis based on log-transformed data. Back-transformed mean presented with 95% confidence interval in parenthesis. ANCOVA with post hoc tests were applied for pairwise group comparison on BAFF and APRIL. All analyses were adjusted for age and sex. Alpha level was adjusted due to multiple comparisons (Bonferroni).