Table 2.

Associations Between PRS and Case-Control Status Stratified by the Presence of OCs

			P T < 5 × 10−8			P T < 10−6
Sample		N	exp(B)	R 2	P	exp(B)	R 2	P
Sweden	All	547	1.48	0.030	2.2E-04	1.59	0.053	1.9E-06
	OCs−	368	1.49	0.040	7.8E-04	1.57	0.050	1.1E-04
	OCs+	179	1.18	0.006	.34	1.62	0.046	.01
Verona	Alla	298	1.03	0.000	.85	1.12	0.003	.45
	OCs−	154	0.97	0.000	.86	1.03	0.000	.87
	OCs+	76	1.17	0.004	.57	1.23	0.007	.45
MFS	Alla	170	1.13	0.002	.71	1.22	0.006	.6
	OCs−	48	0.82	0.005	.65	0.86	0.003	.73
	OCs+	28	1.95	0.061	.26	3.08	0.112	.15
UKB	All	220 908	1.26	0.003	2.8E-04	1.33	0.005	8.0E-06
	OCs−	198 739	1.27	0.003	3.6E-04	1.33	0.004	2.2E-05
	OCs+	22 169	1.16	0.001	.39	1.30	0.004	.154

Note: MFS, Maudsley Family Study; OC, obstetric complication; PRS, polygenic risk score; UKB, UK Biobank. Association between PRS and case-control status in the total sample (All), the subsample without OCs history (OCs−), and the subsample with OCs history (OCs+). R², the Nagelkerke R². Significant results in bold.

^aIn Verona and MFS, the total sample (All) is higher than the sum of the OCs− and OCs+ as individuals with missing OC data were included.