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Interaction Between PRS and OCs on Case-Control Status
| PRS at PT< 5 × 10−8 | PRS at PT< 10−6 | ||||
|---|---|---|---|---|---|
| Sample | N eff | exp(B) | P | exp(B) | P |
| Sweden | 537 | 0.73 | .18 | 0.99 | .96 |
| Verona | 218 | 1.24 | .59 | 1.25 | .57 |
| MFS | 53 | 3.20 | .22 | 4.20 | .18 |
| UKB | 1302 | 0.92 | .66 | 0.98 | .90 |
Note: MFS, Maudsley Family Study; OC, obstetric complication; PRS, polygenic risk score; UKB, UK Biobank. Coefficients and P-values from the interaction term PRS*OC in the logistic regression model. Neff, Effective sample sizes.
