Table 4.

Recommendations on the Management of Clozapine-Withdrawal-Induced Catatonia

Recommendations	Type	Level of Evidence	Strength of Recommendation
Avoid abrupt discontinuation of clozapine to minimise risk of clozapine-withdrawal-induced catatonia	Consensus based	-	-
If feasible, re-initiate clozapine	Evidence-based	(III) evidence from non-experimental descriptive study	(C) Directly based on category III evidence
Consider benzodiazepine as an adjunctive treatment	Evidence-based	(III) evidence from non-experimental descriptive study	(C) Directly based on category III evidence
Where re-initiation of clozapine or use of benzodiazepines is not feasible, consider ECT	Evidence-based	(III) evidence from non-experimental descriptive study	(C) Directly based on category III evidence