Table 5.

Recommendations on the Management of Clozapine-Withdrawal-Induced Serotonergic Discontinuation Symptoms

Recommendations	Type	Level of Evidence	Strength of Recommendation
Avoid abrupt discontinuation of clozapine to minimise risk of clozapine-withdrawal-induced serotonergic discontinuation symptoms	Consensus based	-	-
Cease any concomitant serotonergic medications and provide supportive care	Evidence-based	(III) Evidence from non-representative surveys or case reports	(C) Directly based on category III evidence
Consider short-term use of cyproheptadine in moderate and severe cases	Evidence-based	(III) Evidence from non-representative surveys or case reports	(C) Directly based on category III evidence
If feasible, re-initiate clozapine	Consensus based	-	-