Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 7;12:807015. doi: 10.3389/fimmu.2021.807015

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Sepúlveda-Yáñez, Alvarez Saravia, Pilzecker, van Schouwenburg, van den Burg, Veelken, Navarrete, Jacobs and Koning

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Corrected incidence of tandem dinucleotide substitutions in MSH2/6 deficiency. (A) Dinucleotide substitutions from unique IGHV sequences obtained from constitutional mismatch repair deficiency (CMMRD) patients and corrected after in silico predictions of dinucleotide substitutions that did not occur in tandem. Burgundy cells represent sequence inversions, light and dark purple cells represent juxtalocations of the 5’ and 3’ base in the pair (as seen from the non-transcribed strand), respectively. For unshaded cells, juxtalocation could not be assessed due to one or more nucleotides in the reference sequence matching the mutated sequence. (B) Relative contribution of sequence inversions and juxtalocations.