Fig. 1.

Processing pipeline of representative OS superficial complex OCT-A images from a proband (A–G) and healthy control (H–N). (A, H) Raw OCT-A image; (B,I) contrast-limited adaptive histogram equalization (CLAHE) filtered image; (C, J) bias field corrected image to reduce intensity inhomogeneity; (D, K) top and bottom hat filtered image for vessel enhancement; (E, L) binarized image; (F, M) FAZ-centered ETDRS grid used for masking OCT-A image for blue central (d = 1 mm), green parafoveal (d = 3 mm), and orange perifoveal (d = 4.7 mm) regions; (G, N) ETDRS-masked binarized image. OS = oculus sinister; OCT-A = optical coherence tomography angiography; FAZ = foveal avascular zone; ETDRS = Early Treatment Diabetic Retinopathy Study. For color, please see the figure online.