Table 2.
Nonparametric Analysis of Retinal Vascular Measures Comparing SZ to HCs
| Layer | OU | OD | OS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HC | SZ | Cohen’s d | P | HC | SZ | Cohen’s d | P | HC | SZ | Cohen’s d | P | ||
| Superficial | VD | 0.33 (0.016) | 0.333 (0.018) | 0.19 | .81 | 0.315 (0.02) | 0.325 (0.019) | 0.52 | .14 | 0.352 (0.018) | 0.349 (0.022) | −0.12 | .72 |
| SVD | 0.088 (0.004) | 0.09 (0.005) | 0.38 | .36 | 0.085 (0.005) | 0.088 (0.005) | 0.65 | .044* | 0.094 (0.005) | 0.094 (0.006) | 0.038 | .84 | |
| VDI | 3.717 (0.093) | 3.687 (0.13) | −0.27 | .32 | 3.673 (0.10) | 3.652 (0.15) | −0.16 | .41 | 3.75 (0.10) | 3.717 (0.14) | −0.28 | .44 | |
| FD | 1.65 (0.007) | 1.653 (0.008) | 0.36 | .29 | 1.648 (0.009) | 1.653 (0.008) | 0.51 | .08~ | 1.657 (0.009) | 1.658 (0.01) | 0.10 | .57 | |
| Deep | VD | 0.268 (0.023) | 0.265 (0.026) | −0.14 | .35 | 0.233 (0.021) | 0.234 (0.037) | 0.036 | .91 | 0.308 (0.027) | 0.299 (0.028) | −0.32 | .18 |
| SVD | 0.09 (0.006) | 0.088 (0.007) | −0.16 | .30 | 0.08 (0.009) | 0.08 (0.01) | 0.008 | 1 | 0.101 (0.008) | 0.098 (0.008) | −0.34 | .14 | |
| VDI | 2.981 (0.062) | 2.976 (0.079) | −0.063 | .75 | 2.895 (0.079) | 2.90 (0.10) | 0.062 | .89 | 3.067 (0.078) | 3.055 (0.077) | −0.15 | .60 | |
| FD | 1.653 (0.012) | 1.652 (0.012) | −0.15 | .47 | 1.639 (0.017) | 1.638 (0.018) | −0.045 | .77 | 1.671 (0.015) | 1.668 (0.014) | −0.25 | .26 | |
| Choriocapillaris | VD | 0.378 (0.008) | 0.38 (0.009) | 0.34 | .29 | 0.362 (0.011) | 0.370 (0.013) | 0.65 | .044* | 0.394 (0.013) | 0.392 (0.012) | −0.18 | .57 |
| SVD | 0.119 (0.002) | 0.12 (0.002) | 0.44 | .18 | 0.115 (0.002) | 0.118 (0.003) | 0.79 | .017* | 0.123 (0.004) | 0.123 (0.003) | −0.12 | .71 | |
| VDI | 3.162 (0.023) | 3.160 (0.022) | −0.075 | .83 | 3.136 (0.037) | 3.141 (0.029) | 0.15 | .49 | 3.20 (0.025) | 3.188 (0.03) | −0.27 | .54 | |
| FD | 1.70 (0.003) | 1.702 (0.004) | 0.39 | .34 | 1.70 (0.003) | 1.701 (0.005) | 0.54 | .14 | 1.703 (0.005) | 1.704 (0.006) | 0.11 | .97 | |
Note: SZ = schizophrenia/schizoaffective; HC = healthy control; OU = oculus uterque; OD = oculus dexter; OS = oculus sinister; VD = vessel density; SVD = skeletonized vessel density; VDI = vessel diameter index; FD = fractal dimension. For both diagnostic groups, vascular measures are given as mean (SD). Retinal vascular measures are adjusted for age, sex, race, visual acuity, OCT-A scanner, image quality, and body mass index.
Trending test statistics are denoted as ~P < .1. Significant test statistics are in bold and denoted as *P < .05.