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Cardiovascular cluster. Twelve pathways in the integrated transcriptome and high-content screening dataset reveal the presence of 18 putative cardiotoxins, which together with 14 clustered drugs can be used to predict the target modulation by this toxin class and the cellular response. This cluster indicates alternating vascular and/or cardiac muscle contraction and relaxation periods, for example based on MLCP inhibition or activation and Na+ and K+ mobilization.
